At least eight people were killed and 10 others received injuries as a result of the collision between a passenger bus and trailer truck on Sukkur-Multan motorway in the wee hours of Monday.
The ill-fated was travelling from Mansehra to Karachi, said Motorway Police official.
Soon after the incident, rescue officials reached the spot and shifted the bodies and injured to Tehsil Hospital Ghotki for medico-legal formalities and treatment.
The deceased included women and children, said police, adding that the condition of four people is critical.
The deceased were identified as Noor Elahi, Shagufta, Rozina, Uneeba and Hasnat.